Monday, February 16, 2009
Read an article few days ago. It said Insulin is a new possible new treatment for Alzheimer's, it helps 2shield neurones from exposing to ADDLs ( amyloid beta-derived diffusible ligands) - It is known to attack memory-forming synapses. After ADDL binding, synapses lose their capacity 2respond to incoming information, so resulting in memory loss. Insulin works as inhibitor 2prevent ADDLs from binding with neurone receptors. Therefore, it reduces de actual number of ADDL binding sites, which in turn resulted in a marked reduction of ADDL attachment to synapses. ( I guess it's about competitive inhibition.) However, sensitivity to insulin can decline with aging. The Namenda ( Alzheimer's drug) only partially protect neurone against the effect of ADDLs. In Alzheimer's disease, when ADDLs bind to nearby neurons, they cause damage from free radical n a loss of neuronal structures which is crucial to brain function. Now the problem is ADDLs bounds to synapses remove insulin receptors from nerve cells. So, it only found out that remove ADDL receptors may determine whether a person develops Alzheimer's disease. I sincerely hope that dey will find out a cure for dis disease. Keep fighting for de research team!!! =)
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